部分原文报道如下：

 

　　The European Commission requested EFSA to assess the acute exposure to glycerol (E 422) from slush ice drinks and de-alcoholised wine. The acute exposure assessment was conducted on a single‑consumption‑event basis considering the reported use levels and analytical data of glycerol in slush ice drinks and the proposed maximum level of 50,000 mg glycerol/L in de-alcoholised wine. The Panel considered that a conservative dose above which unintended pharmacological effects would occur should be used for the determination of the acute reference dose (ARfD). based on Wald and McLaurin (1982) study, the Panel derived an ARfD of 125 mg glycerol/kg body weight for a single consumption event. The Panel concluded that the acute exposure to glycerol per single consumption event from slush ice drinks, assuming a consumption of 250 mL and 500 mL for children and other population groups, respectively, would exceed the ARfD for all population groups. The Panel also concluded that the P95 acute exposure estimates for glycerol, at the proposed maximum level, from the potential use of de‑alcoholised wine, assumed to be consumed by children and adolescents as a substitute for flavoured drinks and by other population groups as a substitute for wine and wine-like drinks, would exceed the ARfD for all population groups. As requested by the European Commission, the Panel calculated the maximum single consumption event volume of beverages containing E 422 that can be consumed by different populations groups without exceeding the ARfD. The Panel also calculated the theoretical maximum levels of E 422 when used as a food additive in beverages, including slush ice drinks and de-alcoholised wine, at which exposure does not exceed the ARfD in different population groups. The Panel recommends the European Commission to consider establishing numerical maximum levels for glycerol (E 422) when used in beverages.

 

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