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欧盟评估转基因枯草芽孢杆菌菌株Glu3-3生产的谷氨酰胺酶的安全性

时间:2026-05-07

   食品伙伴网讯  2026年5月6日,欧盟食品安全局就一种谷氨酰胺酶(glutaminase)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因枯草芽孢杆菌菌株Glu3-3生产的,旨在用于七种食品生产过程。
 
  经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏反应的风险,但这种情况发生的可能性很低。因为没有证据表明食品酶中不存在来自生产生物体的DNA,所以专家组无法对食品酶的安全性做出结论。部分原文报道如下:
 
  The food enzyme glutaminase (l-glutamine amidohydrolase; EC 3.5.1.2) is produced with the genetically modified Bacillus subtilis strain Glu3-3 by Angel Yeast Co., Ltd. The production strain of the food enzyme contains multiple copies of acquired antimicrobial resistance genes. The food enzyme was considered free of viable cells of the production strain, but the absence of DNA was not demonstrated. As no other concerns arising from the microbial source or from the manufacturing process have been identified, the Panel considered that toxicological tests are not needed for the assessment of this food enzyme. The food enzyme is intended to be used in seven food manufacturing processes. Dietary exposure was estimated to be up to 29.311 mg total organic solids/kg body weight per day in European populations. A search for the homology of the amino acid sequence of the glutaminase to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. Because the absence of DNA from the production organism in the food enzyme was not demonstrated, the Panel could not conclude on the safety of the food enzyme.
 
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