经过评估，专家小组认为该添加剂对目标物种、消费者和环境是安全的。评估中的添加剂被认为是所有非反刍动物物种氨基酸L-组氨酸的有效来源。为了使补充的L-组氨酸对反刍动物和非反刍动物同样有效，需要防止其在瘤胃中降解。部分原文报道如下：

 

　　Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-histidine monohydrochloride monohydrate produced with a genetically modified strain of Escherichia coli (CCTCC M 20241089) as a nutritional additive in feed and water for drinking for all animal species and categories. l-Histidine monohydrochloride monohydrate manufactured by fermentation with E. coli CCTCC M 20241089 did not give rise to any safety concern regarding the genetic modifications of the production strain. No viable cells nor DNA of the production strain were detected in the final product. The use of l-histidine monohydrochloride monohydrate produced with E. coli CCTCC M 20241089 in feed is safe for the target species when supplemented in appropriate amounts to the diet according to their nutritional needs. The FEEDAP Panel had concerns on the use of l-histidine monohydrochloride monohydrate in water for drinking. The use of l-histidine monohydrochloride monohydrate produced by fermentation with E. coli CCTCC M 20241089 in animal nutrition was considered safe for the consumers of products from animals receiving the additive, and for the environment. The FEEDAP Panel could not conclude on the potential of the additive to be an irritant to skin and/or eyes and to be a potential skin sensitiser. The additive was regarded as an effective source of the amino acid L-histidine for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.

 

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