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欧盟评估大肠杆菌CCTCC M 2024517生产的L-色氨酸作为所有动物饲料添加剂的安全性和有效性

时间:2025-10-23

   食品伙伴网讯  2025年10月22日,据欧盟食品安全局EFSA)消息,应欧盟委员会要求,欧盟动物饲料添加剂和产品(FEEDAP)研究小组就大肠杆菌CCTCC M 2024517生产的L-色氨酸(L‐tryptophan)作为所有动物饲料添加剂的安全性和有效性发表科学意见。
 
  经过评估,专家小组认为该添加剂对目标物种、消费者和环境是安全的。评估中的添加剂被认为是所有非反刍动物物种氨基酸L-色氨酸的有效来源。为了使补充的L-色氨酸对反刍动物和非反刍动物同样有效,需要防止其在瘤胃中降解。部分原文报道如下:
 
  Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-tryptophan produced with a genetically modified strain of Escherichia coli (CCTCC M 2024517) as a nutritional additive in feed and water for drinking for all animal species and categories. The l-tryptophan produced by fermentation with E. coli CCTCC M 2024517 did not give rise to any safety concern regarding the genetic modifications of the production strain. No viable cells nor DNA of the production strain was detected in the final product. The use of l-tryptophan produced with E. coli CCTCC M 2024517 in feed is safe for the target species when supplemented in appropriate amounts to the diet according to their nutritional needs. The FEEDAP Panel had concerns on the use of l-tryptophan in water for drinking. The use of l-tryptophan produced by fermentation with E. coli CCTCC M 2024517 in animal nutrition was considered safe for the consumers of products from animals receiving the additive and for the environment. The FEEDAP Panel could not conclude on the potential of the additive to be an irritant to skin and/or eyes and to be a potential skin sensitiser. The additive was regarded as an effective source of the amino acid l-tryptophan for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.
 
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